http://www.molecularbrain.com/comments The latest comments on all articles published by Molecular Brain 2012-05-14T10:09:59Z http://www.molecularbrain.com/content/1/1/11/comments#791696 <p>Here is some additional information on the working memory test we used in this article. <br/> <br/>Now, we published a movie article showing the detailed protocol for the test utilizing an automatic T-maze apparatus in Journal of Visualized Experiments. <br/> <br/>Shoji, H., Hagihara, H., Takao, K., Hattori, S., Miyakawa, T. T-maze Forced Alternation and Left-right Discrimination Tasks for Assessing Working and Reference Memory in Mice. J. Vis. Exp. (60), e3300, DOI: 10.3791/3300 (2012). <br/>http://www.jove.com/video/3300 <br/> <br/>This movie article would be useful, if you are not familiar with the test and want to do similar experiments.</p> Tsuyoshi Miyakawa 2012-05-14T10:09:59Z http://www.molecularbrain.com/content/1/1/11 Takao et al. Molecular Brain 1 11 Wed Oct 22 09:37:59 BST 2008 http://www.molecularbrain.com/content/1/1/6/comments#554695 <p>1. This paper was translated into Belorussian language, thanks to the effort of Nadejda Dobkina. <br/>http://onlinepharmacycheck.com/~doc/molecularbrain-content-be <br/> <br/>2. Now, we are showing how to take out whole dentate gyrus from mice in a video journal, Journal of Visualized Experiments (JoVE). The gene expression differences in the DG of alpha-CaMKII HKO mice are much more clearer (See the text in the JoVE article). <br/>http://www.jove.com/details.php?id=1543 <br/> <br/>3. We have demonstrated that chronic fluoxetine (a SSRI; Prozac) treatment causes "dematuration" of almost all DG granule cells, causing dramatic changes of electrophysiological properties of DG neurons and resulting in a phenotype we call "immature dentate gyrus (iDG)" (Kobayashi et al., PNAS, 2010). Transcriptome pattern in the hipocampus of SSRI-treated wild type mice is strikingly similar to the ones seen in the alpha-CaMKII HKO mice. In fact, iDG-like phenomena can be seen a few other genetically-engineered mice and other drug-treated mice (our unpublished observation).</p> Tsuyoshi Miyakawa 2012-01-06T09:36:30Z http://www.molecularbrain.com/content/1/1/6 Yamasaki et al. Molecular Brain 1 6 Wed Sep 10 18:01:32 BST 2008