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Open Access Highly Accessed Review

Expression of NMDA receptor-dependent LTP in the hippocampus: bridging the divide

Tim VP Bliss13 and Graham L Collingridge23

Author Affiliations

1 Division of Neurophysiology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK

2 Centre for Synaptic Plasticity, School of Physiology and Pharmacology, University of Bristol, Bristol BS8 1TD, UK

3 Department of Brain & Cognitive Sciences, College of Natural Sciences, Seoul National University, Rm 330, Bldg. 501 Shilim, Gwanak, Seoul, 151-746, Korea

Molecular Brain 2013, 6:5  doi:10.1186/1756-6606-6-5

Published: 22 January 2013

Abstract

A consensus has famously yet to emerge on the locus and mechanisms underlying the expression of the canonical NMDA receptor-dependent form of LTP. An objective assessment of the evidence leads us to conclude that both presynaptic and postsynaptic expression mechanisms contribute to this type of synaptic plasticity.