Fragile X mental retardation protein and synaptic plasticity
The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139 46-3301, USA
Molecular Brain 2013, 6:15 doi:10.1186/1756-6606-6-15Published: 8 April 2013
Loss of the translational repressor FMRP causes Fragile X syndrome. In healthy neurons, FMRP modulates the local translation of numerous synaptic proteins. Synthesis of these proteins is required for the maintenance and regulation of long-lasting changes in synaptic strength. In this role as a translational inhibitor, FMRP exerts profound effects on synaptic plasticity.