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Open Access Highly Accessed Review

Fragile X mental retardation protein and synaptic plasticity

Michael S Sidorov, Benjamin D Auerbach and Mark F Bear*

Author Affiliations

The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139 46-3301, USA

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Molecular Brain 2013, 6:15  doi:10.1186/1756-6606-6-15

Published: 8 April 2013

Abstract

Loss of the translational repressor FMRP causes Fragile X syndrome. In healthy neurons, FMRP modulates the local translation of numerous synaptic proteins. Synthesis of these proteins is required for the maintenance and regulation of long-lasting changes in synaptic strength. In this role as a translational inhibitor, FMRP exerts profound effects on synaptic plasticity.

Keywords:
FMRP; Protein synthesis; Synaptic plasticity; Long-term depression; Long-term potentiation; Metabotropic glutamate receptor; Fragile X