Open Access Research

Mind bomb-1 is an essential modulator of long-term memory and synaptic plasticity via the Notch signaling pathway

Ki-Jun Yoon1, Hye-Ryeon Lee2, Yong Sang Jo4, Kyongman An5, Sang-Yong Jung5, Min-Woo Jeong5, Seok-Kyu Kwon6, Nam-Shik Kim1, Hyun-Woo Jeong1, Seo-Hee Ahn3, Kyong-Tai Kim5, Kyungmin Lee7, Eunjoon Kim6, Joung-Hun Kim5, June-Seek Choi4, Bong-Kiun Kaang23 and Young-Yun Kong1*

  • * Corresponding author: Young-Yun Kong ykong@snu.ac.kr

  • † Equal contributors

Author Affiliations

1 Department of Biological Sciences, College of Natural Sciences, Seoul National University, San 56-1 Silim-dong Gwanak-gu, Seoul, 151-747, South Korea

2 National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University, Gwanangno 599, Gwanak-gu, Seoul, 151-747, South Korea

3 Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul, 151-747, South Korea

4 Department of Psychology, Korea University, 5-1 Anam-dong Seongbuk-gu, Seoul, 136-701, South Korea

5 Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk, 790-784, South Korea

6 National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, 305-701, South Korea

7 Department of Anatomy, School of Medicine, Kyungpook National University, 2-101, Dongin-Dong, Daegu, 700-422, South Korea

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Molecular Brain 2012, 5:40  doi:10.1186/1756-6606-5-40

Published: 30 October 2012

Abstract

Background

Notch signaling is well recognized as a key regulator of the neuronal fate during embryonic development, but its function in the adult brain is still largely unknown. Mind bomb-1 (Mib1) is an essential positive regulator in the Notch pathway, acting non-autonomously in the signal-sending cells. Therefore, genetic ablation of Mib1 in mature neuron would give valuable insight to understand the cell-to-cell interaction between neurons via Notch signaling for their proper function.

Results

Here we show that the inactivation of Mib1 in mature neurons in forebrain results in impaired hippocampal dependent spatial memory and contextual fear memory. Consistently, hippocampal slices from Mib1-deficient mice show impaired late-phase, but not early-phase, long-term potentiation and long-term depression without change in basal synaptic transmission at SC-CA1 synapses.

Conclusions

These data suggest that Mib1-mediated Notch signaling is essential for long-lasting synaptic plasticity and memory formation in the rodent hippocampus.

Keywords:
Mind bomb-1; Notch; Synaptic plasticity; Memory; Hippocampus