Molecular Brain

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Open Access Review

Imaging synaptic plasticity

Zahid Padamsey and Nigel J Emptage*

Author Affiliations

Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK

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Molecular Brain 2011, 4:36 doi:10.1186/1756-6606-4-36

Published: 29 September 2011

Abstract

Over the past decade, the use and development of optical imaging techniques has advanced our understanding of synaptic plasticity by offering the spatial and temporal resolution necessary to examine long-term changes at individual synapses. Here, we review the use of these techniques in recent studies of synaptic plasticity and, in particular, long-term potentiation in the hippocampus.

Keywords:
synaptic plasticity; long-term potentiation; electrophysiology; optical imaging; FM dyes; Ca2+ imaging; single particle tracking; pHlourins; FRET; FLIM