Presenilins and the gamma-secretase: still a complex problem

doi:10.1186/1756-6606-3-7

Molecular Brain

Volume 3

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Foa L

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Presenilins and the gamma-secretase: still a complex problem

David H Small , David W Klaver and Lisa Foa

Molecular Brain 2010, 3:7doi:10.1186/1756-6606-3-7


Published:	5 February 2010

Abstract (provisional)

The presenilins form part of a complex of membrane proteins that are involved in the proteolytic cleavage of cell-surface molecules. This article reviews the history of the discovery of the presenilins, their role in the pathogenesis of Alzheimer's disease and in the metabolism of the amyloid-beta precursor protein. Unanswered questions about their biochemical mechanism of action and their effects on Ca2+ homeostasis are examined.

Presenilins and the gamma-secretase: still a complex problem

Abstract (provisional)

The complete article is available as a provisional PDF. The fully formatted PDF and HTML versions are in production.