Figure 6.

Involvement of GSK3β in Aβ impairment of AMPAR trafficking. Inhibition of GSK3β by a specific inhibitor SB415286 abolished both Aβ-induced loss of AMPARs from spine surface (a) and Aβ-inhibition of AMPAR insertion during chemical LTP (b) as revealed by SEP-GluR1 imaging. Double asterisks: p < 0.005; triple asterisks: p < 0.0005 (comparing to the control, Student's t-test).