Figure 2.

Protein synthesis and degradation is required to appropriately incorporate partially modified information. A, Schematic view of the task. The process is similar as in Figure 1A, except that the mice have received intrahippocampal injection right after day 2 exposure. B, Cannula location in the hippocampus, at two different rostro-caudal planes. Numbers indicate the posterior direction from the bregma. Grey, blue, red, and purple circles indicate the infusion site of vehicle, βlac, anisomycin, and βlac plus anisomycin double infusion group, respectively. C, Preference to unswitched and switched objects at the third day (Veh, vehicle, n = 10; Ani, anisomycin, n = 7; βlac, clasto-lactacystin-β-lactone, n = 7; Ani+ βlac, n = 4. F = 9.869, p = 0.0002; one-way ANOVA. *p < 0.05, **p < 0.01, ***p < 0.001; unpaired t test). D, Preference to unswitched and switched objects at the second day.