Short report
Protein synthesis and degradation are required for the incorporation of modified information into the pre-existing object-location memory
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* Corresponding author: Bong-Kiun Kaang Kaang@snu.ac.kr
1 National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University, 151-742 Seoul, Korea
2 Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, 151-742 Seoul, Korea
Molecular Brain 2010, 3:1 doi:10.1186/1756-6606-3-1
Published: 8 January 2010Abstract
Although some reports indicate that protein synthesis dependent process may be induced by updating information, the role of protein synthesis and degradation in changing the content of pre-existing memory is yet unclear. In this study, we utilized an object rearrangement task, in which partial information related to a pre-existing memory is changed, promoting memory modification. Inhibitors of both protein synthesis and protein degradation impaired adequate incorporation of the altered information, each in a distinctive way. These results indicate that protein synthesis and degradation play key roles in memory modification.