Table 2 |
||||
|
Summary of the involvement of NMDA receptor NR2B subunit in behavioral memory and chronic pain |
||||
|
Brain function |
Drug or manipulation |
Brain regions |
Effects |
Reference |
|
|
||||
|
Spatial memory (Morris water maze) |
NR2B overexpression |
Forebrain |
Enhanced fear memory |
Tang et al., 1999 |
|
|
||||
|
NR2B antagonist |
Systemic injection |
No effect |
Guscott et al., 2003 |
|
|
|
||||
|
Fear memory |
NR2B overexpression |
Forebrain |
Enhanced fear memory |
Tang et al., 1999 |
|
NR2B antagonist |
Amygdala |
Blocked acquisition |
Rodrigues et al., 2001 |
|
|
No effect on expression of fear |
||||
|
NR2B antagonist |
Amygdala |
Inhibit fear conditioning without effect on fear expression |
Walker and Davis, 2008 |
|
|
|
||||
|
Chronic pain |
NR2B overexpression |
Forebrain |
Enhancing chronic pain |
Wei et al., 2002 |
|
NR2B antagonist |
ACC |
Inhibiting chronic pain |
Wu et al., 2005 |
|
|
|
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|
Zhuo Molecular Brain 2009 2:4 doi:10.1186/1756-6606-2-4 |
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