Molecular Brain

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Open Access Research

Critical involvement of Rho GTPase activity in the efficient transplantation of neural stem cells into the injured spinal cord

Fujiki Numano1,2, Akihiro Inoue1, Mitsuhiro Enomoto2,3, Kenichi Shinomiya2, Atsushi Okawa2 and Shigeo Okabe1,4*

Author Affiliations

1 Department of Cell Biology, School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyo-ku, Tokyo 113-8519, Japan

2 Department of Orthopaedic and Spinal Surgery, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyo-ku, Tokyo 113-8519, Japan

3 Developmental Division of Advanced Orthopaedic Therapeutics, Graduate School, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8519, Japan

4 Department of Cellular Neurobiology, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan

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Molecular Brain 2009, 2:37 doi:10.1186/1756-6606-2-37

Published: 28 November 2009

Additional files

Additional file 1:

The proportion of in vitro differentiation in each adenovirus infected cell. The immunocytochemical analysis was performed for in vitro-expanded NSPCs three days after withdrawal of bFGF. There were no significant differences between the phenotypes of NSPCs infected with recombinant adenoviruses and noninfected control cells.

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