hTDP-43 promotes dendritic branching in Drosophila neurons and disease-related mutations in hTDP-43 reduce this activity. (A-D) Images of ddaE and ddaF neurons that express mCD8-GFP (A), wildtype hTDP-43 (B), hTDP-43 with the Q331K mutation (C), and hTDP-43 with the M337V mutation (D). The asterisk indicates another sensory neuron in the cluster that occasionally was weakly labeled with GFP expressed with the Gal4221 driver. (E) Quantification of dendritic ends of ddaE neurons. (F) Quantification of dendritic ends of ddaF neurons. The number of neurons examined is indicated in each column. Values are mean ± SEM. ***P < 0.001.
Lu et al. Molecular Brain 2009 2:30 doi:10.1186/1756-6606-2-30