Figure 6.

hTDP-43 promotes dendritic branching in Drosophila neurons and disease-related mutations in hTDP-43 reduce this activity. (A-D) Images of ddaE and ddaF neurons that express mCD8-GFP (A), wildtype hTDP-43 (B), hTDP-43 with the Q331K mutation (C), and hTDP-43 with the M337V mutation (D). The asterisk indicates another sensory neuron in the cluster that occasionally was weakly labeled with GFP expressed with the Gal4²²¹ driver. (E) Quantification of dendritic ends of ddaE neurons. (F) Quantification of dendritic ends of ddaF neurons. The number of neurons examined is indicated in each column. Values are mean ± SEM. ***P < 0.001.