Table 1 |
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|
Effects of ablated neurogenesis on learning and memory. |
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|
Ablation method |
Extent of ablation |
Behavior task tested |
Species (Strain) |
Effect |
Ref |
|
|
|||||
|
MAM |
~84% |
Trace eye blink conditioning |
Rat (Sprague-Dawley) |
- |
[4] |
|
~84% |
Delayed eye blink conditioning |
Rat (Sprague-Dawley) |
· |
[4] |
|
|
~75% |
Morris water maze |
Rat (Sprague-Dawley) |
· |
[6] |
|
|
~85% |
Trace fear conditioning |
Rat (Sprague-Dawley) |
- |
[6] |
|
|
~85% |
Contextual fear memory |
Rat (Sprague-Dawley) |
· |
[6] |
|
|
Irradiation |
~85% * |
Contextual fear memory |
Mouse (129SvEv) |
- |
[3] |
|
~85% * |
Cued fear memory, Morris water maze, Y maze |
Mouse (129SvEv) |
· |
[3] |
|
|
~75% |
Radial arm maze (hippocampus dependent) |
Mouse (129SvEv) |
+ |
[7] |
|
|
~90% |
Morris water maze |
Rat (Long Evans) |
· |
[8] |
|
|
~90% |
Morris water maze (only long-term memory) |
Rat (Long Evans) |
- |
[8] |
|
|
Transgenic |
~85% * |
Contextual fear memory |
Mouse (C57BL6-BALBc mixed) |
- |
[3] |
|
~85% * |
Cued fear memory |
Mouse (C57BL6-BALBc mixed) |
· |
[3] |
|
|
~75% |
Radial arm maze (hippocampus dependent) |
Mouse (C57BL6-BALBc mixed) |
+ |
[7] |
|
|
N. S. |
Barnes maze, Contextual fear memory |
Mouse (C57BL/6J) |
- |
[5] |
|
|
N. S. |
Cued fear memory |
Mouse (C57BL/6J) |
· |
[5] |
|
|
~66% |
Contextual fear memory, Cued fear memory |
Mouse (backcrossing to C57BL/6J) |
· |
[9] |
|
|
|
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|
Many studies have reported a relationship between hippocampal neurogenesis and memory. This table summarizes debates about the role of neurogenesis in learning and memory. N.S., not stated in paper; *, inferred from previous paper; +/•/-, ablation of neurogenesis enhances/has no effect on/impairs the described task. |
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|
Ko et al. Molecular Brain 2009 2:1 doi:10.1186/1756-6606-2-1 |
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