Table 1

Differentially Expressed Probes in the Schizophrenic Patients of the Schizophrenia-enriched Cluster.

Expression

Probe ID

Gene Name

p-value (t-Test)

FC Signed Magnitude

Gene Symbol

UP

213920_at

Cut-like 2 (Drosophila)

6.38E-06

2.77

CUTL2

UP

215532_x_at

Zinc finger protein 492

1.30E-06

2.44

ZNF492

UP

214735_at

Phosphoinositide-binding protein PIP3-E

1.19E-04

2.4

PIP3-E

UP

220232_at

Stearoyl-CoA desaturase 4, biosynthesis of monounsaturated fatty acids from saturated fatty acids

2.35E-05

2.34

SCD4

UP

204730_at

Regulating synaptic membrane exocytosis 3 (RIMS3), Ca2+-binding C2 domain

2.02E-04

2.22

RIMS3

UP

216153_x_at

Reversion-inducing-cysteine-rich protein with kazal motifs

1.92E-04

2.21

RECK

UP

216511_s_at

Transcription factor 7-like 2 (T-cell specific, HMG-box) (T-cellspecific transcription factor 4)

1.04E-03

2.19

TCF7L2(TCF4)

UP

215182_x_at

mRNA; cDNA DKFZp586E121 (from clone DKFZp586E121)

9.75E-04

2.12

unknown

UP

216037_x_at

Transcription factor 7-like 2 (T-cell specific, HMG-box) (T-cellspecific transcription factor 4)

9.49E-05

2.04

TCF7L2(TCF4)

UP

215801_at

mRNA; cDNA DKFZp434G1615 (from clone DKFZp434G1615)

7.57E-05

2.01

unknown

UP

222249_at

KIAA1651 protein

1.03E-03

2.01

unknown

DOWN

209687_at

Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)

2.79E-03

-2.01

CXCL12

DOWN

206662_at

Glutaredoxin (thioltransferase)

2.70E-04

-2.04

GLRX

DOWN

207768_at

Early growth response 4

8.53E-03

-2.06

EGR4

DOWN

208650_s_at

CD24 antigen (small cell lung carcinoma cluster 4 antigen)

3.43E-04

-2.21

CD24

DOWN

203235_at

Thimet oligopeptidase 1

3.05E-03

-2.25

THOP1

DOWN

214432_at

ATPase, Na+/K+ transporting, alpha 3 polypeptide

2.43E-04

-2.28

ATP1A3

DOWN

202802_at

Deoxyhypusine synthase

3.39E-03

-2.34

DHPS

DOWN

205626_s_at

Calbindin 1, 28 kDa

5.36E-05

-2.46

CALB1

DOWN

219389_at

Hypothetical protein FLJ10052

6.06E-05

-2.71

FLJ10052

DOWN

266_s_at

CD24 antigen (small cell lung carcinoma cluster 4 antigen)

3.91E-04

-2.75

CD24

DOWN

207307_at

5-hydroxytryptamine(serotonin) receptor 2C

1.49E-03

-2.82

HTR2C

DOWN

208651_x_at

CD24 antigen (small cell lung carcinoma cluster 4 antigen)

4.25E-05

-2.92

CD24

DOWN

206935_at

Protocadherin 8

1.46E-06

-2.92

PCDH8

DOWN

216379_x_at

CD24 antigen (small cell lung carcinoma cluster 4 antigen)

4.17E-06

-2.97

CD24

DOWN

209771_x_at

CD24 antigen (small cell lung carcinoma cluster 4 antigen)

2.30E-05

-3.23

CD24

Total 26 probes were determined as highly significantly affected independently from age and gender in schizophrenic patients of their specific cluster. Neurogenesis-related genes are shown in italics and cell maturation/migration-related genes are in bold. Note that calbindin, a maker for mature neurons in DG, is significantly downregulated in the schizophrenic patients.

Yamasaki et al. Molecular Brain 2008 1:6   doi:10.1186/1756-6606-1-6