Research
Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders
- † Equal contributors
Molecular Brain 2008, 1:6 doi:10.1186/1756-6606-1-6
Research
Research
Molecular Brain 2008, 1:6 doi:10.1186/1756-6606-1-6
Additional Information
Tsuyoshi Miyakawa (2012-01-06 09:36) Fujita Health University
1. This paper was translated into Belorussian language, thanks to the effort of Nadejda Dobkina.
http://onlinepharmacycheck.com/~doc/molecularbrain-content-be
2. Now, we are showing how to take out whole dentate gyrus from mice in a video journal, Journal of Visualized Experiments (JoVE). The gene expression differences in the DG of alpha-CaMKII HKO mice are much more clearer (See the text in the JoVE article).
http://www.jove.com/details.php?id=1543
3. We have demonstrated that chronic fluoxetine (a SSRI; Prozac) treatment causes "dematuration" of almost all DG granule cells, causing dramatic changes of electrophysiological properties of DG neurons and resulting in a phenotype we call "immature dentate gyrus (iDG)" (Kobayashi et al., PNAS, 2010). Transcriptome pattern in the hipocampus of SSRI-treated wild type mice is strikingly similar to the ones seen in the alpha-CaMKII HKO mice. In fact, iDG-like phenomena can be seen a few other genetically-engineered mice and other drug-treated mice (our unpublished observation).
Competing interests
None declared
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