Editorial
Starting at the endophenotype: A role for alpha-CaMKII in schizophrenia?
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* Corresponding author: Paul W Frankland paul.frankland@sickkids.ca
1 Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, M5G 1X8, Canada
2 Department of Physiology, University of Toronto, Toronto, M5S 1A8, Canada
3 Institute of Medical Science, University of Toronto, Toronto, M5S 1A8, Canada
Molecular Brain 2008, 1:5 doi:10.1186/1756-6606-1-5
Published: 10 September 2008Abstract
Using an endophenotype-driven screen, a new study finds that α-calcium/calmodulin kinase II mutant mice exhibit a range of behavioral abnormalities related to schizophrenia. Perhaps most strikingly, this cluster of schizophrenia-related endophenotypes was associated with abnormal neurogenesis in the adult hippocampus, raising the possibility that disrupted adult neurogenesis lies at the core of this and other psychiatric disorders.